博研生物抗體，“胰島素受體α抗體,Anti-Insulin Receptor alpha抗體*格”應(yīng)用于IHC、WB、 IF、IP、ELISA，質(zhì)量保證，無效免費退換，另外本公司生產(chǎn)經(jīng)營各種標記二抗、免疫印跡常用試劑、免疫組化常用試劑，咨詢！

產(chǎn)品介紹：

【產(chǎn)品名稱】：胰島素受體α抗體,Anti-Insulin Receptor alpha抗體*格

【產(chǎn)品類型】：一抗

【產(chǎn)品編號】：BYk-0047R

【相關(guān)標記】: HRP Biotin Gold RBITC AP FITC Cy3 Cy5 Cy5.5 Cy7 PE PE-Cy3 PE-CY5 PE-CY5.5 PE-CY7 APC Alexa Fluor 350 Alexa Fluor 488 Alexa Fluor 555 Alexa Fluor 647

【性 狀】： Lyophilized or Liquid

【濃 度】： 1mg/1ml

【亞 型】： IgG

【規(guī) 格】：0.1ml/100ug，0.2ml/200ug

【抗體來源】： Rabbit OR MOUSE

【克隆類型】： polyclonal or monoclonal

【產(chǎn)品用途】：科研實驗，用于免疫組化實驗，WB實驗、IF、IP、ELISA實驗，相應(yīng)的標記抗體有HRP標記抗體，F(xiàn)ITC標記，BIO等。

【貯 存】： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
Important Note This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

【信息詳情】： The human insulin receptor is a heterotetrameric membrane glycoprotein consisting of disulfide linked subunits in a beta-alpha-alpha-beta configuration. The beta subunit （95 kDa） possesses a single transmembrane domain, whereas the alpha subunit （135 kDa） is compley extracellular. The insulin receptor exhibits receptor tyrosine kinase （RTK） activity. RTKs are single pass transmembrane receptors that possess intrinsic cytoplasmic enzymatic activity, catalyzing the transfer of the gamma phosphate of ATP to tyrosine residues in protein substrates. RTKs are essential components of signal transduction pathways that affect cell proliferation, differentiation, migration and metabolism.
Included in this large protein family are the insulin receptor and the receptors for growth factors such as epidermal growth factor, fibroblast growth factor and vascular endothelial growth factor. Receptor activation occurs through ligand binding, which facilitates receptor dimerization and autophosphorylation of specific tyrosine residues in the cytoplasmic portion. The interaction of insulin with the alpha subunit of the insulin receptor activates the protein tyrosine kinase of the beta subunit, which then undergoes an autophosphorylation that increases its tyrosine kinase activity. Three adapter proteins, IRS1, IRS2 and Shc, become phosphorylated on tyrosine residues following insulin receptor activation. These three phosphorylated proteins then interact with SH2 domain containing signaling proteins.

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