Interacts with EIF1AD, USP25, PRKCI and WARS. Subcellular Location : Cytoplasm, cytosol. Nucleus. Cytoplasm, perinuclear region. Membrane. Note=Translocates to the nucleus following S-nitrosylation and interaction with SIAH1, which contains a nuclear localization signal. Postnuclear and Perinuclear regions. Post-translational modifications : S-nitrosylation of Cys-152 leads to interaction with SIAH1, followed by translocation to the nucleus. ISGylated (Probable). Sulfhydration at Cys-152 increases catalytic activity. Similarity : Belongs to the glyceraldehyde-3-phosphate dehydrogenase family. 甘油醛-3-磷酸脫氫酶(Glyceraldehyde 3 phosphate dehydrogenase,GAPDH)是糖酵解(glycolysis)過(guò)程中的關(guān)鍵酶。除了在胞質(zhì)中作為糖酵解的酶以外,有證據(jù)表明哺乳動(dòng)物細(xì)胞中的GAPDH參與了多種胞內(nèi)生化過(guò)程,包括膜融合(membrane fusion)、微管成束(microtubule